My place is close to the National Zoo, a great location in a nice area. I live 4 blocks from the Woodley Park/ Zoo/ Adam's Morgan metro station, which is 1 stop from Dupont Circle (nightlife) and 3 stops from downtown (National Mall area). My place is good for couples and solo adventurers, who are in town, although I'll give priority to solo travelers just to keep things simpler.
I've lived here for 7 years. DC is a great city and I can let you know about local attractions/events.